All the tasks that are related to making your site faster should be as automated as much as possible. No one likes optimising photos with Photoshops "Save For Web" or pasting unminified code to a web app and then copying it from there. All these tasks can be automated by using the modern web development tools.
The Compass built in mixin is bit sucky, here's better.
Everything you know about Media Queries is wrong. Not really, but I kinda felt like that when I dug more into it. Sass (SCSS), of course, does all the dirty work for us.
It seems really kinda mysterious thing, to use ems or px, or maybe rems? But in reality it's really quit simple.
For instance, Compass has a reset, but no Normalize, nor animation. Fret not, plugins are here to help.
Club-Mate, the beverage → club-mate.fi